Antibiotic Resistance Threats in the United States, 2019. Atlanta, GA: U.S. Department of Health and Human Services, CDC; 2019.https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. https://www.cdc.gov/cdiff/what-is.html.
 https://www.cdc.gov/cdiff/pdf/FS-Cdiff-PatientsFamilies-508.pdf, https://www.cdc.gov/cdiff/clinicians/index.html;
 https://www.cdc.gov/drugresistance/about.html; Fluent MT, Jacobsen PL, Hicks LA; OSAP, the Safest Dental Visit. Considerations for responsible antibiotic use in dentistry. J Am Dent Assoc. 2016;147(8):683-686. Palmer NO, Woodward J.
 https://www.cdc.gov/antibiotic-use/data/outpatient-prescribing/index.html, https://www.cdc.gov/antibiotic-use/data/report-2021.html.
 Bye M, Whitten T, Holzbauer S. Antibiotic Prescribing for Dental Procedures in Community-Associated Clostridium difficile cases, Minnesota, 2009–2015. Open Forum Infect Dis. 2017;4(Suppl 1):S1. Published 2017 Oct 4.
 https://www.osap.org/antibiotic-stewardship-for-prescribers, https://www.mi-marr.org/dental-resources/ .
 Schaudinn C, Gorur A, Keller D, Sedghizadeh PP, Costerton JW. Periodontitis: an archetypical biofilm disease. J Am Dent Assoc. 2009;140(8):978-986.
 Perio Gel™ with 1.7% hydrogen peroxide via Perio Tray™ delivery, Perio Protect LLC, St. Louis, MO, USA. Peroxide needs time to work. The optimal treatment time with Perio Tray™ delivery is 15-minute applications. Putt MS, Mallatt ME, Messmann LL, Proskin HM. A 6-month clinical investigation of custom tray application of peroxide gel with or without doxycycline as adjuncts to scaling and root planing for treatment of periodontitis. Am J Dent. 2014;27(5):273-284. Putt MS, Proskin HM. Custom tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis: a randomized, controlled three-month clinical trial. J Clin Dent. 2012;23(2):48-56. Putt MS, Proskin HM. Custom tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis: results of a randomized controlled trial after six months. J Clin Dent. 2013;24(3):100-107. Cochrane RB, Sindelar B. Case Series Report of 66 Refractory Maintenance Patients Evaluating the Effectiveness of Topical Oxidizing Agents. J Clin Dent. 2015;26(4):109-114. Keller DC and Cochrane B. Composition of Microorganisms in Periodontal Pockets. JOHD 2019:2(2):123-36.
 Krayer JW, Leite RS, Kirkwood KL. Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases. Dent Clin North Am. 2010;54(1):13-33. Charles CH, Mostler KM, Bartels LL, Mankodi SM. Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. J Clin Periodontol. 2004;31(10):878-884.
 Dunlap T, Keller DC, Marshall MV, et al. Subgingival delivery of oral debriding agents: a proof of concept. J Clin Dent. 2011;22(5):149-15. Keller DC and Cochrane B. Composition of Microorganisms in Periodontal Pockets. JOHD 2019:2(2):123-36.
 Ibid. For more information on the chemistry and safety of hydrogen peroxide, see Marshall MV, Cancro LP, Fischman SL. Hydrogen Peroxide: A Review of Its Use in Dentistry. J Periodontol. 1995 Sept;66(9):786-96.